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{{Skip to talk}} {{WikiProject banner shell|class=C|1= {{WikiProject Epilepsy|importance=mid}} {{WikiProject Medicine|importance=low|neurology=yes|neurology-imp=Mid|psychiatry=yes|psychiatry-imp=Mid}} {{WikiProject Psychology|importance=Mid}} }} {{Reliable sources for medical articles}} {{DSM copyright}} {{Talk header<!-- |search=yes -->|disclaimer=yes|bottom=yes}} {{merged-from|Hystero-epilepsy|April 22, 2012}} {{TOC right}} ==Psychogenic seizures not psychogenic?== I removed the assertion that psychogenic seizures are not psychogenic. This article is about psychogenic seizures. Other sorts of seizures, non-psychogenic in origin, are detailed in articles listed under 'see also'. Repeatedly explaining, in an article called "psychogenic seizures," that psychogenic seizures are not psychogenic is confusing and ultimately pointless. This would be similar to repeated assertions in the article entitled [[Dog]], that dogs are not in fact dogs but are cats. If someone wants to create a section entitled "Controversy," with text along the lines of "Some authorities have stated that psychogenic seizures do not exist ''per se''," that might be a good idea. It would need, however, to be cited, as with any other contribution to Wikipedia, because Wikipedia [[WP:NOR|forbids original research]]. I am eager, of course, to learn of the existence of any such verifiable statements, and strongly suggest that if they exist they be placed into the article. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 23:13, 12 April 2006 (UTC) In my opinion the person who wrote the current article on Psychogenic Non-Epileptic Seizures has an "agenda". The article is clearly imbalanced and attempts to whitewash issues of psychiatric predisposition as well as issues of malingering (wherein "seizures" are used to motivate some form of social gain such as may occur when "seizures" are attributed to an auto or industrial accident potentially tied to financial incentive). Whoever wrote the article probably has some form of practice wherein he/she manages these patients. In practice an accurate diagnosis of psychogenic seizures, malingering, or frank fraud are anathema because they generate patient hostility, billing problems, and possibly even retribution law suits. However, even though rigorous avoidance of accuracy may understandable in some contexts, this is no place to do such a dance. The article needs to be written by someone who is willing to look at the complex issues accurately and without a hidden agenda. The introductory sentence "There is no scientific consensus as to what causes PNES. However, many physicians believe the condition may be triggered by psychological problems..." seems problematic because PNES is by definition psychological in origin. [[User:Gomer2|Gomer2]] ([[User talk:Gomer2|talk]]) 11:34, 31 May 2018 (UTC) Gomer2, I just saw your comment. Yes, there is indeed a problem here, in that the name "psychogenic nonepileptic seizures" implies a known causation, but in reality, the causes of PNES are still a matter of debate. But the solution to this problem is not to assert that the causation mentioned in the name must be correct by definition. The solution is to change the name. There is an increasing trend in the literature to refer to these seizures using more neutral terms, such as :non-epileptic attack disorder" or "functional nonepileptic seizures". I think we are getting to the point where we need to consider changing the title of this page to reflect these recent changes (while still ensuring that searches for PNES redirect here).[[User:Wilshica|Wilshica]] ([[User talk:Wilshica|talk]]) 01:10, 14 June 2021 (UTC) Wilshica == Flashlight seizures == [[Photosensitive epilepsy]] are of an epilepic origin ,and shouldt be a part of this article [[User:Diza|The Procrastinator]] 21:57, 29 December 2005 (UTC) I think what you meant to say is that photosensitive epilepsy is non-epileptic in origin and should be a part of this article. Both assertions are wrong. -[[User:Ikkyu2|Ikkyu2]] 02:47, 30 December 2005 (UTC) == Why is 'seizures' plural in the article name? == The article discusses a syndrome of recurrent seizures which has no better singular name. An isolated psychogenic seizure does not qualify as conversion disorder, does not require treatment, and in general is different than the syndrome which is discussed in the article. Refer to [http://en.wikipedia.org/wiki/Wikipedia_talk:Naming_conventions/archive5#SOME_article_titles_should_be_plural] for more. -[[User:Ikkyu2|Ikkyu2]] 23:42, 20 January 2006 (UTC) == Revert to recent edit. == A recent edit included the following text, which I've reverted. Discussion follows: <blockquote>In the past the patient with psychogenic non-epileptic seizures was thought to have a history of childhood physical abuse or sexual abuse or other severe emotional trauma. Treatment, with cognitive therapy or behavioral therapy, would be focused on strategies to recognize the onset of the seizures and use techniques to abort them, or to interrupt the stimulus-response pathway that produces them.<p> This is now largely discredited with only a few Psychiatrists willing to pursue this line. These tend to be non-organic such as the leading exponent Douglas Turkington who has led research into the abuse causes of seizures. Turkington holds that even though the patient and their family may not remember the abuse this is because the abuse is repressed (see Freud and the unconscious). As no empirical proof can be provided for this theory other specialists regard such theories as pseudo-science.<p> This is even more true given the fact that most epilepsy specialists recognise that a) some seizures, especially complex frontal lobe, are very hard to diagnose b) respone to medication is no indication of the pseudo nature of the seizure as patients diagnosed with epilepsy frequently do not respond to treatment.</blockquote> * "In the past, the patient with PNES was thought to have a history of childhood physical or sexual abuse." That's not what this paragraph, which I wrote, originally said. It said that such patients were '''often''' found to '''give''' such a history. That's still true, and I've reverted it to say "sometimes found to give such a history." Mangling text - sourced text, no less - to distort its meaning and then rebutting it is poor editing form, and I request that you not do so in the future. * According to Betts, 1997, in EPILEPSY: A COMPREHENSIVE TEXTBOOK, (see article for reference) cognitive behavioral therapy is still the mainstay of treatment technique. If you are going to cite a different theory, such as Mr Turkington's, please provide a [[WP:V|verifiable]] reference published by a reputable source. * The paragraph about frontal lobe seizures is not relevant to an article section about the treatment of non-epileptic seizures. Non-epileptic seizures are not caused by epilepsy. If you wish to assert, in an article called 'Psychogenic non-epileptic seizures,' that non-epileptic seizures are caused by epilepsy, I suggest creating a section called 'Criticism' or 'Controversy' and placing your assertions there. If the assertions are not verifiably referenced, they will be removed. [[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 19:43, 16 February 2006 (UTC) :Also, honestly, I can't understand how editors to this page can use the term '''pseudoseizures''', right after the introduction to the article asserts that that term should never be used. I encourage people thinking of editing the article to read it first. If you're going to write paragraphs about pseudoseizures, at least delete the part where the article admonishes readers never to use the term. [[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 03:37, 17 February 2006 (UTC) == Names == ===Non-epileptic Attack Disorder=== I've created [[Non-epileptic attack disorder]] (NEAD) as a redirect to this excellent article. It appears that there is a US/UK split on terminology here, possibly resulting from the influence of Dr Tim Betts (former editor of the journal Seizure and advisor to Epilepsy Action). The two big UK charities have articles referring to NEAD rather than PNES ([http://www.epilepsy.org.uk/info/nonep.html Epilepsy Action], [http://www.e-epilepsy.org.uk/pages/articles/show_article.cfm?id=48 The National Society for Epilepsy]). Searches for NEAD on PubMed tend to show UK research. I wonder if it we should mention "Non-epileptic Attack Disorder (NEAD)" in the article - otherwise folk may wonder if it is a different thing. I do think there is a subtle difference between NEAD and PNES. NEAD, in using the term "Disorder" appears to be more like a diagnosis/disease. Whereas PNES is a label for symptoms or the manifestation of a disease. (Apologies if I'm not using the precise medical terms here). Ikkyu2 - The NSE online article mentioned above is written by Tim Betts, who is also the author of one of your references. I can't read the book. However, reading the online article I suspect the article and the chapter have much in common. If you agree, I suggest this article be added to either the External Links or perhaps in the References as an option for those unable to consult the book. :I agree without any reservation. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 21:22, 1 March 2006 (UTC) ===Non-epileptic seizures=== [[Non-epileptic seizures]] is currently a redirect to this article. There is much confusion online as to whether NES is exactly equivalent to PNES. Many NES articles appear to be discussing only psychological causes. Some online articles discussing NES split them into physiological causes and psychogenic causes. I guess the former group get less written attention and are less likely to be given the label "NES" for any length of time, since the patient is then quickly then diagnosed with (and treated for) their physiological condition. I suspect most NES articles are written by folk who are only interested in the PNES aspect. The book "Differential Diagnosis in Adult Neuropsychological Assessment" ({{ISBN|0826116655}}) has a section headed "Non-Epileptic Seizures" on p109. This says "Non-epileptic seizures are seizures that do not original from a primary neurological cause in the brain. The two types of non-epileptic seizures are ''physiological'' and ''psychogenic''. Physiological non-epileptic seizures are caused by medical conditions in an organ system other than the brain, such as cardiovascular abnormalities, most commonly syncope. ...". I can't read any of the book "Non-Epileptic Seizures, 2nd edition" ({{ISBN|0750670266}}), but from its [http://www.intl.elsevierhealth.com/catalogue/title.cfm?ISBN=0750670266 contents listing] it does not appear to discuss physiological conditions. I wonder if it would be good to promote [[non-epileptic seizures]] to being an article of its own. The contents of the "Other non-epileptic seizures" section could go there, as could some of the similar material in the "Diagnosis" section of the [[epilepsy]] article. Both this article and the epilepsy article could then have a "See also" to NES. The DAB link at the top of [[seizure]] could then point at [[Non-epileptic seizures]]. An even more radical thought would be to move [[seizure]] to [[epileptic seizure]] and make [[seizure]] into a DAB article. I would vote for that since I think it is best to be specific in the name of the article. :I agree; I think all 3 of these articles should at least link to each other in their ''See also'' sections. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 21:22, 1 March 2006 (UTC) :With regard to the idea of promoting non-epileptic seizures to its own article, I think that the things that are non-epileptic seizures divide into two categories: psychogenic seizures, and misdiagnosis. People can shake during a syncopal attack, but that doesn't make it a seizure; it makes it a syncope that can be misdiagnosed as a seizure. People can lose the thread of conversation during a migraine aura, but that doesn't make it a non-epileptic complex partial seizure; it's still a migraine headache. People can shake all over due to non-epileptic myoclonus, but what's the point of calling that a seizure? It's myoclonus. These things are not seizures, unless you want to warp the word seizure to mean something that no one expects it to mean, and I don't think that's a particularly good idea. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 01:58, 3 March 2006 (UTC) :I agree with what you've said, from a precise and medical point-of-view. Can I just check – do you no longer think it is useful to create such an article? I still think it is possible to have a [[Non-epileptic seizures]] article that carefully discusses the two causes (physiological and psychogenic) and does indeed mention that (after investigation and diagnosis) the former would then be no longer called a ''seizure'' by a physician, but he/she would then use the more accurate term appropriate for the actual underlying disease. :However, I think the public use the term ''seizure'' in a more general sense than a careful physician would. In the medical world, with the need not to cause any confusion, the term has become exclusively associated with epileptic seizures. Some non-medical dictionary definitions are (excluding the act of taking something): :*A sudden attack (as of disease) <an epileptic seizure> – ''Webster's'' :*A very sudden attack of an illness involving unconsciousness or violent movement – ''Cambridge Advanced Learner's Dictionary'' :*OLD USE a sudden failure of the heart – ''Cambridge Advanced Learner's Dictionary'' :*A seizure is also the sudden loss of control of your muscles and, often, the loss of consciousness, caused by certain medical conditions – ''Cambridge Dictionary of American English'' :*a sudden manifestation or recurrence of a disease, such as an epileptic convulsion – ''Collins'' :*a sudden attack of illness, especially a stroke or an epileptic fit. – ''Compact Oxford English Dictionary'' :*A sudden attack, spasm, or convulsion, as in epilepsy or another disorder – ''The American Heritage Dictionary of the English Language'' :*The meaning "sudden attack of illness" is attested from 1779 – ''Online Etymological Dictionary'' :In my research for [[List of people believed to have epilepsy]], I have read many news stories where the words ''seizure'' or ''fit'' are used very casually. Any article should be clear on the medical profession's use of the term ''seizure''. At the same time, we must accept that people will call all sorts of things ''a seizure''. --[[User:Colin|Colin]] 13:58, 3 March 2006 (UTC) ::I think I'm handicapped by my POV on this one. I've studied this for so many years, and I'm so convinced I'm right :) , that it's hard for me to know exactly what the more typical encyclopedia reader would find useful. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 00:30, 7 March 2006 (UTC) ===Pseudoseizures=== Whilst I agree the term pseudoseizures is unsatisfactory, we have perhaps yet to find the ideal term. See {{PMID|14630495}} for a study from the patient's point of view. The following statistics are also interesting: * '''non-epileptic attack disorder''' - 19 PubMed Articles, 281 Google results * '''psychogenic non-epileptic seizures''' - 25 PubMed Articles, 477 Google results * '''non-epileptic seizures''' - 92 PubMed Articles, 16,300 Google results, this recent book on Amazon: {{ISBN|0750670266}} * '''pseudoseizures''' - 233 PubMed Articles, 25,100 Google results, this recent book on Amazon: {{ISBN|1904424279}} The term pseudoseizures still appears in recent articles and books - it is not going away quickly --[[User:Colin|Colin]] 17:58, 17 February 2006 (UTC) Well, it redirects here (to PNES) in both singular and plural forms, and it's bolded in the introduction. It's deprecated for good reasons - it's stigmatizing and strictly inaccurate. I would say that it is going away about as quickly as the term 'epileptic idiot' went away in terms of describing the developmentally delayed person with epilepsy, which is to say, no conceivable speed could be fast enough. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 21:22, 1 March 2006 (UTC) :This isn't just my own personal POV, by the way; although it happens to be, it is also clearly explained, in exactly the way it's explained here in the linked article from the Epilepsy Foundation on PNES. -[[User:Ikkyu2|<span style="color:#2000C0;">ikkyu2</span>]] ([[User_talk:Ikkyu2|<span style="color:#00FF00;">talk</span>]]) 02:00, 3 March 2006 (UTC) I often find it a shame that valid scientific names are deprecated because they may "connote" something in the uneducated eye of the beholder. There are many medical and scientific terms in pseudo- and people should be educated to understand what it means. [[User:Dadge|Dadge]] ([[User talk:Dadge|talk]]) 11:07, 14 August 2015 (UTC) == what can cause them? == In the paragraph "Causes", there is the sentence "A history of abuse or other psychological trauma is often present as a causative factor", and then a request for citation needed. I would propose the following article as a well done study in reputable medical journal: Nonepileptic seizures and childhood sexual and physical abuse. Kenneth Alper, Orrin Devinsky, Kenneth Perrine, Blanca Vazquez, Daniel Luciano. Neurology, 1993, 43(10). Pubmed ID: 8413951 https://doi.org/10.1212/WNL.43.10.1950 <!-- Template:Unsigned IP --><small class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/70.20.25.26|70.20.25.26]] ([[User talk:70.20.25.26#top|talk]]) 13:22, 30 September 2018 (UTC)</small> <!--Autosigned by SineBot--> i was wondering what sort of things can cause seizures? i read party pills can as can low blood sugars but i was wondring about like alchohol and thing like that???? ([[User:203.109.241.127|203.109.241.127]] 03:48, 25 March 2006 (UTC)) :This isn't the relevent article to answer your question. Have a look at [[epilepsy#Causes|Epilepsy:Causes]], though that doesn't really cover one-off [[seizure]]s. Seizures can be provoked by taking certain drugs and alcohol (and also during withdrawal). [[User:Colin|Colin]]°[[User talk:Colin|<sup>Talk</sup>]] 10:08, 25 March 2006 (UTC) == Removed unsupported assertion == I removed the following text from the article: : Treatment based on insight-oriented techniques or exploring of abuse histories has not been found to be effective.... Instead, treatment with [[cognitive therapy]] or [[behavioral therapy]] is focused on concrete strategies to recognize the triggers of the seizures and use techniques to control them and eventually halt the onset. Those statements are not supported by the references provided. None of the references provided even mentions non-epileptic seizures or their treatment. There appears to be very little evidence regarding effective treatment for this condition. I did find one study, [http://www.ncbi.nlm.nih.gov/pubmed/18395473 here], which supports CBT. But I'm not sure that one study warrants inclusion in the encyclopedia.[[User:Twerges|Twerges]] ([[User talk:Twerges|talk]]) 08:12, 9 March 2009 (UTC) == Removal of unsupported claims in Treatment section == There was some question about my edit [http://en.wikipedia.org/w/index.php?title=Psychogenic_non-epileptic_seizures&diff=275989814&oldid=274424120 here]. Another editor claimed on my user page that: : [The edit] removed information that was referenced properly. The claims were not referenced properly. The claims are followed by references which do not support the claims at all. For example, take the reference from the mayo clinic website. It says this about treatment: : Seeing a psychologist or professional counselor can help treat symptoms of conversion disorder and prevent it from coming back. This can be especially helpful if you have anxiety, a mood disorder such as depression or other mental health issues. That does not support the superiority of CBT over insight therapy for this condition. In fact, it does not even mention either CBT or insight therapy. The other references are even less related to the claims. Most of the references either do not mention CBT or do not mention PNES. One of the references is a general criticism of psychotherapy research and has nothing to do with this topic. Another reference has a malformed URL and goes nowhere. The only reference which has any support at all for the claims made was [http://serendip.brynmawr.edu/exchange/node/1803 here]. However, that reference only includes support in the "user comments" section at the bottom of the article, in which anonymous users wrote comments like "CBT worked for me" and so on. That is not an acceptable reference for the claims made, since user comments are not reliable according to [[WP:RS]]. When I did a quick search of pubmed, I found little support for the claims which I deleted. I found exactly one study which supported CBT for this condition: {{PMID|18395473}}. That study does not compare the effectiveness of CBT versus insight therapy for this condition. [[User:Twerges|Twerges]] ([[User talk:Twerges|talk]]) 19:28, 5 April 2009 (UTC) ::Thank you for the clarification. I confess I did not go to the original soruces to verify that they stated what they were being used to support. My oversight, sorry and thanks. --[[User:PaulWicks|PaulWicks]] ([[User talk:PaulWicks|talk]]) 19:38, 5 April 2009 (UTC) ==Overhauling the article== I am attempting to upgrade this article from a slightly woolly hodgepodge of polemics to a decent article. I'm currently integrating a lot of content from Dr Mellor's recent review and will go out and find some more recent references to weave in once I'm done. All assistance gratefully received! Cheers, --[[User:PaulWicks|PaulWicks]] ([[User talk:PaulWicks|talk]]) 20:24, 5 April 2009 (UTC) ==Merger proposal== The article [[Hystero-epilepsy]] is somewhat unclear, but looks to me to be suggesting that an anecdote about Charcot is worth an entire encyclopedia article. I disagree and suggest we mention "Hystero-epilepsy" as an outdated term for PNES in the article here and delete the Hystero-epilepsy article. Whaddya reckon? --[[User:PaulWicks|PaulWicks]] ([[User talk:PaulWicks|talk]]) 21:21, 5 April 2009 (UTC) :Yes, I concur. That article is a stub, and has been for quite a while. It's unlikely it will ever be developed further. Merging is a good plan. --[[User:Jack-A-Roe|Jack-A-Roe]] ([[User talk:Jack-A-Roe|talk]]) 21:33, 5 April 2009 (UTC) ::Only if you can find a reliable source that says Hystero-epilepsy was actually a form of psychogenic non-epileptic seizures. It looks that way, and a peculiar one at that -- where the patients presented having nothing resembling epilepsy but were placed in a ward with "similar" patients who displayed "epileptic" attacks and they then hysterically "caught" epilepsy from them. If you do merge, it needs to have its own section and made quite clear that this was an invented disease and a product of the hospital care these women received. PNES is not an invented disease. [[User:Colin|Colin]]°[[User talk:Colin|<sup>Talk</sup>]] 22:04, 5 April 2009 (UTC) :::Colin, I think those are fair suggestions and align with what I had in mind. I will await a few more comments before taking action (or not), maybe later this week. --[[User:PaulWicks|PaulWicks]] ([[User talk:PaulWicks|talk]]) 07:51, 6 April 2009 (UTC) The hystero-epsily section really needs to be removed outright. It's irrelevant to the actual topic at hand, and makes the article confusing to read. Anyone disagree? [[Special:Contributions/50.135.73.142|50.135.73.142]] ([[User talk:50.135.73.142|talk]]) 02:09, 21 June 2012 (UTC) :Hi there, I'd say it can probably be trimmed but retained. I will take a scalpel to it and see what we think. --[[User:PaulWicks|PaulWicks]] ([[User talk:PaulWicks|talk]]) 08:53, 21 June 2012 (UTC) ::Looks much better to me. Thanks for the edit. [[Special:Contributions/50.135.73.142|50.135.73.142]] ([[User talk:50.135.73.142|talk]]) 05:34, 23 June 2012 (UTC) == Factitious Seizures? == I query whether the author may have gotten his or her wires crossed in the "Distinguishing Features" section. The diagnostic criteria for NEAD are stated earlier in the article as including an absence of malingering - why, then, does the author use the work 'faking' in the final line of this section? "Mellors et al. warn that such tests are neither conclusive nor impossible for a determined patient with factitious disorder to "pass" through faking convincingly." <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/138.253.244.181|138.253.244.181]] ([[User talk:138.253.244.181|talk]]) 09:16, 27 September 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot--> == Trying to introduce a note of caution and balance == Hi all, This page is looking quite good, but I did notice some rather bold claims e.g. PNES are caused by childhood trauma and repressed memories. They could well be, but many would disagree. That's just one hypothesis. It would be nice to raise the evidential standards on this page a little, if not to the level of mainstream medical pages, at least a bit higher. I've made a few attempts, but would welcome feedback and further contributions. Things I found concerning (you might spot others): - there is no scientific consensus as to what causes PNES. We have various theories - all quite different - but they are no more than that. In some places, theory was presented as fact, and this is a bad look. - there is some evidence to support a role for past trauma, and some to support a role for personality characteristics. But also plenty of studies that support neither.. Need to show balance here. - when describing theories that are contentious and widely disputed, the phrasing didn't always make that clear. e.g., Instead of "PNES are caused by childhood abuse", better to say "One theory is that PNES are caused by childhood abuse" (then give supporting evidence and alternative views) Further suggestions, feedback welcome. <small><span class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Wilshica|Wilshica]] ([[User talk:Wilshica|talk]] • [[Special:Contributions/Wilshica|contribs]]) 01:35, 20 July 2015 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot--> == Wiki Project Med student editor == Hello PNES editors, I am a medical student at Tel Aviv University who was assigned this article as part of a wikimed elective course. This article is currently listed as "start-class" so I intend to contribute new portions (e.g. causes, mechanism, pathophysiology, etc.) in an appropriate format. I am collaborating with a member of the [[International League Against Epilepsy|ILEA]] to facilitate neutral improvements. Please reach out to me with comments/questions/concerns regarding my edits.[[User:Gomer2|Gomer2]] ([[User talk:Gomer2|talk]]) 18:59, 28 February 2018 (UTC) Added "History & Culture" section. Added "Epidemiology" section. Added "Signs & Symptoms" section. Modified "Treatment" section to include (1) clarify importance of education in treatment and (2) difficulty falling through cracks (between psychiatry and neurology) Modified "Diagnosis" section: 1. "capturing one or two episodes on both videotape..."; videotape is outdated technology 2. Saying EEG tests have high false-positive rate is inaccurate and has more to do with EEG interpretation. false-negative also occurs but apparently can be identified as such. In any case, conventional EEG is not the most relevant for PNES...sticking instead to long-term video-EEG monitoring. 3. goals (#1-4) of EEG-video monitoring modified Intro: PNES are by definition psychological. Added "Causes" section: [[User:Gomer2|Gomer2]] ([[User talk:Gomer2|talk]]) 12:31, 31 May 2018 (UTC) ::Sounds good. And welcome. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 20:05, 3 June 2018 (UTC) ==Moved here== {{refbegin}} * {{cite journal|last=Ahmad|first=S|author2=Beckett, MW |title=Value of serum prolactin in the management of syncope|journal=Emergency medicine journal : EMJ|date=March 2004|volume=21|issue=2|pages=e3|pmid=14988379|doi=10.1136/emj.2003.008870|pmc=1726305}} * {{cite book|last=Betts|first=T|editor-last=Engel|editor-first=Jerome|editor-last2=Pedley|editor-first2=Timothy A.|editor-last3=Aicardi|editor-first3=Jean|title=Epilepsy: A Comprehensive Textbook|url=https://books.google.com/books?id=6Kq4Zt2KOpcC|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-5777-5|chapter=Conversion Disorders}} {{refend}} Unclear if these are used in the article as references? [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 20:05, 3 June 2018 (UTC) == Wiki Edit Class Project == Hello all, I am an undergraduate student studying psychology and am in my fourth year. I have been researching PNES for all four years of my undergraduate career and will be making edits to this article under the supervision of my PI and a PhD student. My main goals for this article are to update the citations and ensure the citations come from credible scientific sources, among other things. I am linking my sandbox here: https://en.wikipedia.org/wiki/User:SkyM99/Psychogenic_non-epileptic_seizure for anyone to review who may be concerned/interested in my change ideas. This is obviously a work-in-progress and I am still a student, I believe everyone is still a student in this topic, so bear with me! <!-- Template:Unsigned --><span class="autosigned" style="font-size:85%;">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:SkyM99|SkyM99]] ([[User talk:SkyM99#top|talk]] • [[Special:Contributions/SkyM99|contribs]]) 19:28, 21 March 2021 (UTC)</span> <!--Autosigned by SineBot--> [[User:Wilshica|Wilshica]] ([[User talk:Wilshica|talk]]) 01:00, 14 June 2021 (UTC)== Risk factors == I think the article would be improved if risk factors were defined more narrowly, in line with the use of the term in epidemiology, to include those factors that have genuine predictive value (that is, are associated with increased probability of receiving the diagnosis relative to someone without that factor). This definition would exclude vague psychological constructs like "symptom focusing" as there is no evidence that measures of this construct (even if they could be agreed upon), have any value as predictors of a PNES diagnosis. I have attempted a rephrase. [[User:Wilshica|Wilshica]] ([[User talk:Wilshica|talk]]) 01:00, 14 June 2021 (UTC) wilshica == Follow-up for ReACT treatment == There has been a follow-up study regarding the ReACT treatment for PNES (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633863/). Could anybody more versed in this topic than I include this information in the article? <!-- Template:Unsigned IP --><small class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/2003:DC:1F2F:34E8:7422:6787:E37E:F460|2003:DC:1F2F:34E8:7422:6787:E37E:F460]] ([[User talk:2003:DC:1F2F:34E8:7422:6787:E37E:F460#top|talk]]) 00:27, 7 January 2022 (UTC)</small> <!--Autosigned by SineBot--> ==Wiki Education Foundation-supported course assignment== [[File:Sciences humaines.svg|40px]] This article was the subject of a Wiki Education Foundation-supported course assignment, between <span class="mw-formatted-date" title="2021-01-19">19 January 2021</span> and <span class="mw-formatted-date" title="2021-04-25">25 April 2021</span>. Further details are available [[Wikipedia:Wiki_Ed/University_of_Alabama_at_Birmingham/Psychology_Capstone_(Spring_2021)|on the course page]]. Student editor(s): [[User:SkyM99|SkyM99]]. Peer reviewers: [[User:DanielJanko|DanielJanko]], [[User:Chanda10|Chanda10]]. {{small|Above undated message substituted from [[Template:Dashboard.wikiedu.org assignment]] by [[User:PrimeBOT|PrimeBOT]] ([[User talk:PrimeBOT|talk]]) 07:25, 17 January 2022 (UTC)}} == Removal of bad information in signs and symptoms, treatment, and prognosis == Removed the following claim in "signs and symptoms:" : PNES episodes are nearly indistinguishable from epileptic seizures. The main differences between a PNES episode and an epileptic seizure is the duration of episodes. Epileptic seizures typically last between 30 and 120 seconds depending on the type, while PNES episodes typically last for two to five minutes. which was contradicted by the following in "diagnosis:" : Some features are more or less likely to suggest PNES but they are not conclusive and should be considered in the broader clinical picture. Features that are common in PNES but rarer in epilepsy include: biting the tip of the tongue, seizures lasting more than two minutes (easiest factor to distinguish), seizures having a gradual onset, a fluctuating course of disease severity, the eyes being closed during a seizure, and side to side head movements. Features that are uncommon in PNES include automatisms (automatic complex movements during the seizure), severe tongue biting, biting the inside of the mouth, and incontinence. : If a person with suspected PNES has an episode during a clinical examination, there are a number of signs that can be elicited to help support or refute the diagnosis of PNES. Compared to people with epilepsy, people with PNES will tend to resist having their eyes forced open (if they are closed during the seizure), will stop their hands from hitting their own face if the hand is dropped over the head, and will fixate their eyes in a way suggesting an absence of neurological interference. Moved all of this info from diagnosis into signs and symptoms, and added more details and sources. Removed the following from "treatment," overly detailed and not sourced at all. : Eight points recommended to explain the diagnosis to the person and their caregivers are: :* Reasons for concluding they do not have epilepsy :* What they do have (describe functional neurological disorder) :* Emphasize they are not suspected of "putting on" the attacks, and the symptoms are not "all in their head" :* There may be no triggering "stresses" :* Maintaining factors :* May improve after correct diagnosis :* Caution that anticonvulsant drug withdrawal should be done in conjunction with their physician :* Describe treatment to help regain control of symptoms Removed the following paragraph from "prognosis." The first sentence is directly contradicted by its own source; the others are all sourced from studies from the 90s. Treatment for PNES has greatly improved over the last 30 years, and studies from the 90s of untreated PNES patients aren't good sources for modern PNES prognosis. : Functional seizures have been found to be as disabling and costly as epilepsy. Though there is limited evidence, outcomes appear to be relatively poor with a review of outcome studies finding that two-thirds of people with PNES continue to experience episodes and more than half are dependent on the Social Security program at three-year follow-up. This outcome data was obtained in a referral-based academic epilepsy center and loss to follow-up was considerable; the authors point out ways in which this may have biased their outcome data. Outcome was shown to be better in people with higher IQ, social status, greater educational attainments, younger age of onset and diagnosis, attacks with less dramatic features, and fewer additional somatoform complaints. [[Special:Contributions/137.22.90.64|137.22.90.64]] ([[User talk:137.22.90.64|talk]]) 08:01, 27 May 2024 (UTC) == Merge article to Non-epileptic seizures (or vice-versa) == {{archive top |status = withdrawn |result = I did not format this merge request correctly and have subsequently decided that a merge is not needed at this time. [[User:Slothwizard|Slothwizard]] ([[User talk:Slothwizard|talk]]) 06:48, 1 February 2025 (UTC) }} There is another similar article to this one, [[Non-epileptic seizure|Non-epileptic seizures]], they are talking about the same exact condition. One of these articles should be merged into each other. I propose this article “Psychogenic non-epileptic seizures” be merged into the other, as there is recent evidence that functional seizures may not always have a psychological trigger. The DSM-5 officially refers to functional seizures as “Psychogenic non-epileptic seizures,” so I am okay with having the other article merge into this one, though I believe merging this one to the other would be less confusing. Please discuss so this merge can happen! [[User:Slothwizard|Slothwizard]] ([[User talk:Slothwizard|talk]]) 18:43, 15 September 2024 (UTC) :There are a bunch of non epileptic seizures including those that occur in syncope. PNES is one specific type. [[User:Doc James|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 01:51, 28 January 2025 (UTC) {{archive bottom}} == Major update to article == Hi all! I’ve made substantial edits to the '''Psychogenic non-epileptic seizures''' article with the goal of improving its structure, clarity, and alignment with current clinical evidence. Changes include: * Rewriting the lead to reflect PNES as a functional neurological disorder, clarify diagnostic methods (video-EEG as gold standard), and briefly summarize treatment and prognosis. * Updating the Signs and symptoms and Causes sections to reduce stigma, enhance readability, and better reflect current understanding. * Revising the Diagnosis section for clinical relevance, replacing the DSM-5 bullet list with concise prose, and clarifying outdated tests (e.g. serum prolactin). * Rewriting the Treatment section to emphasize psychotherapy and patient education as first-line care, clarify the limited role of medications, and contextualize emerging therapies (e.g. ReACT). * Expanding Prognosis and Epidemiology using recent studies. * Improving the Society and culture and Terminology sections to reflect current discourse and sources. I’ve aimed to keep the tone encyclopedic and accessible while grounding the text in recent systematic reviews, clinical guidelines, and expert consensus. Further suggestions or improvements are very welcome, especially if you notice areas where additional balance or clarification would help. [[User:Pwoli|Pwoli]] ([[User talk:Pwoli|talk]]) 20:46, 4 May 2025 (UTC) == Merge Proposal of Non-Epileptic Seizures into Psychogenic Non-Epileptic Seizures == I propose merging [[non-epileptic seizure]] into [[Psychogenic non-epileptic seizure]] (this page). Medically, there is no such thing as a "physiological non-epileptic seizure," and NES and PNES are synonymous. There is not a single source in the entire section about "physiological non-epileptic events" in the NES article, and rest of it is just a less substantial restatement of this article. Most of the "physiological non-epileptic seizures" the NES page refers to are differential diagnoses for seizures (narcolepsy, tics, etc), not seizures themselves. They would better fit as a differential diagnosis subsection of this page, as is currently the case on the (epileptic) seizure page. [[User:RhodiumH|RhodiumH]] ([[User talk:RhodiumH|talk]]) 21:33, 24 February 2026 (UTC) :[https://continuum.aan.com/doi/abs/10.1212/CON.0000000000000711 This source] discusses "Nonepileptic Episodic Events" besides PNES [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 23:24, 24 February 2026 (UTC) ::As they explain in their introduction, they do so because one of their focuses is on distinguishing "nonepileptic episodic events" from epileptic seizures, which means other differential diagnoses like convulsive syncope or narcolepsy are relevant. However, they never call any of those "non-epileptic seizures," and they acknowledge that the term generally refers exclusively to PNES: "It is important to note that the term nonepileptic episodic events is also often used interchangeably with nonepileptic seizures or psychogenic nonepileptic seizures (PNES), so caution should be taken to use precise terminology." [[User:RhodiumH|RhodiumH]] ([[User talk:RhodiumH|talk]]) 01:16, 25 February 2026 (UTC) :::{{tq|and they acknowledge that the term generally refers exclusively to PNES}} They do not appear to be saying that in that sentence that you quote (they include an "or" in that sentence). :::However I've just had a look on pubmed and it appears "Non-Epileptic Seizures" almost always refers to PNES. There are [https://pubmed.ncbi.nlm.nih.gov/?term=%22Nonepileptic+Events%22&filter=pubt.review&sort=date various references] to "non-epileptic events" so perhaps the name of the other article should be renamed to that. :::On another note I think a more appropriate name for this article would be "Functional seizures" as that term [https://pubmed.ncbi.nlm.nih.gov/?term=%22functional+seizures%22&filter=pubt.review&filter=years.2020-2026&sort=date seems more common] since 2020 than [https://pubmed.ncbi.nlm.nih.gov/?term=%22psychogenic+non-epileptic+seizures%22&filter=pubt.review&filter=years.2020-2026&sort=date PNES since 2020] (and there isn't a consensus the cause is psychogenic) [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 02:44, 25 February 2026 (UTC) ::::Non-epileptic events is just another term for non-epileptic seizures, which is in turn another term for psychogenic non-epileptic seizures. No need for multiple articles on the same thing. ::::PNES is currently the official name of the condition per the DSM-5, so the article name should probably remain unless there's an official update. (I don't know why it's singular though --- the name is psychogenic non-epileptic seizure''s'', plural.) [[Special:Contributions/~2026-12508-46|~2026-12508-46]] ([[User talk:~2026-12508-46|talk]]) 22:50, 25 February 2026 (UTC) :::::No, sources which discuss non-epileptic events, such as [https://pmc.ncbi.nlm.nih.gov/articles/PMC9647822/ this one], or [https://continuum.aan.com/doi/abs/10.1212/CON.0000000000000711 this one], discuss a variety of non-epileptic events besides PNES. Have you done a search of available [[WP:MEDRS|appropriate sources]] to see what they say about the term? :::::Also, I just checked, and PNES isn't the official name according to the latest version of the DSM-5 (DSM-5-TR). [https://psychiatryonline.org/doi/book/10.1176/appi.books.9780890425787 It] has it under the heading "Functional Neurological Symptom Disorder (Conversion Disorder)" (and also lists various of the different terms that can be used to describe the seizures or attacks, but doesn't give preference to PNES) [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 23:53, 25 February 2026 (UTC) ::::::Are you reading those sources in their entirety, or just judging their contents based on their abstracts? Both make clear in their bodies that they use PNEE/NEEE to refer to differential diagnoses for epilepsy at large, including PNES and other differential diagnoses like syncope. ::::::"Nonepileptic episodic events of physiologic origin may include both '''neurologic and non-neurologic conditions''' '''that could be mistaken for epileptic seizures'''." ::::::"Conditions that could be mistaken for" means "differential diagnoses." The standard on Wikipedia, and what is currently used on the [[seizure]] page, is to include a section on differential diagnoses within the page itself. I propose aligning the PNES page with sitewide standard by merging this page into a section of the PNES page listing its differential diagnoses, which, as your second link discusses, includes syncope, tics, migraine, sleep disorders, and others. That section could mention that these differential diagnoses are sometimes referred to as non-epileptic events during the diagnostic process, but, as you mentioned, NES almost always refers to PNES in a clinical setting. ::::::As for FND, that is a different condition with [[Functional neurological symptom disorder|its own page]]. PNES can be a symptom of FND, but not all FND involves PNES, and it wouldn't be appropriate to merge those pages. [[User:RhodiumH|RhodiumH]] ([[User talk:RhodiumH|talk]]) 18:06, 28 February 2026 (UTC) :::::::Okay, so you acknowledge that the sources discuss non-PNES non-epileptic events then? :::::::There are three questions to consider now, I think. 1. Does the page "non-epileptic seizure" meet wikipedia's notability guideline? 2. Is it better treated as its own page? 3. If it shouldn't be its own page, what is the appropriate page to merge it into? :::::::For the notability question, per [[Wikipedia:GNG]] it has significant coverage in multiple reliable secondary sources, so it is notable. For 3, if it is merged what's the right, page, it seems merging into the differential diagnosis section of [[Epilepsy]] or [[Seizure]] would make a lot more sense than this page, as this page is not about non-epileptic events that aren't PNES. :::::::For whether Non-epileptic events should have its own page, I recommend reading the guidance at [[WP:PAGEDECIDE]], and then taking appropriate action based on that. If that page is merged, I don't think this is the right page to be merged into, so I don't think this talk page is the right place for discussion of that. [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 22:16, 28 February 2026 (UTC) ::::::::Okay after some further thinking in my view we should have a page titled "Paroxysmal non-epileptic events" or "Non-epileptic events". Various reliable sources discuss it as a topic in its own right, so I think it's notable and worthy of its own page. It is, essentially, a page about a type of presentation, and there are various pages like that, such as [[Chest pain]], [[Fatigue]], [[Heartburn]] (there is also a separate page for [[GERD]]), etc. ::::::::I agree that the term "Non-epileptic seizures" should redirect to PNES, however the name of the other page should be changed first, and then the term "Non-epileptic seizures" can be redirected to PNES. [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 00:11, 1 March 2026 (UTC) :::::::::I'm still a bit unsure about this so it may be worth seeing if you can get any input from [[Wikipedia talk:WikiProject Medicine]] [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 00:13, 1 March 2026 (UTC) :PNES include functional (neurologists use more often and so also epileptologists from ILAE )or dissociative seizures( ICH 11 , psychiatrists use more), under broader term FND (functional neurological disorders). This is the current consensus and therefore use of the terms in different subspecialities. :Non epileptic seizures is much broader term including PNES and other movement or episodic disorders related to circulatory causes or sleep related disorders and others(physiological or pathological), which may not need Antiseizure treatment but a different approach to diagnosis and treatment. These entities are not Epileptic seizures because they do not have any abnormal electrical discharges from the brain cells. Nearly 20-30% presentations to clinicians are of this nature and often confused as Epileptic seizures and wrongly treated with not much response. :I feel the article on Non epileptic seizures should remain as such and contains PNES as a section and is broader than that topic so cannot be merged to it. :A separate article on PNES exists which contains the more recently accepted terms like functional or dissociative seizures and should be linked to this article from all other places wherever it may exist. Again PNES ( which may resemble epileptic seizures)also links to FND under which it is an important subsection and integral part besides other functional disorders which may present differently from epileptic seizures. [[User:NandanYardi|NandanYardi]] ([[User talk:NandanYardi|talk]]) 10:09, 1 March 2026 (UTC) ::I agree. I think the page for PNES should be retitled to functional/dissociative seizures since this is what the ILAE has proposed to be the new term for this condition. I think it makes sense to have separate page called non-epileptic events (currently called non-epileptic seizures) where the differential diagnosis for seizure-like events that are not epileptic can be reviewed. [[User:JF1987|JF1987]] ([[User talk:JF1987|talk]]) 15:37, 1 March 2026 (UTC) *Oppose the merge as per the same reasons as before. Non epileptic seizures are a group of conditions. PNES is one single condiction within that group. Why try to confuse things. [[User:Doc James|<span style="color:#0000f1; background:#FFFFFF;">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 13:03, 3 March 2026 (UTC) *:I agree [[User:JF1987|JF1987]] ([[User talk:JF1987|talk]]) 18:53, 4 March 2026 (UTC) *:I agree. Thank [[User:NandanYardi|NandanYardi]] ([[User talk:NandanYardi|talk]]) 10:44, 6 March 2026 (UTC) ==Suggested rename to "Functional/dissociative seizures"== ILAE is suggesting renaming to Functional/dissociative seizures in 2025.[https://onlinelibrary.wiley.com/doi/10.1111/epi.18574] *Pubmed has about 80 papers that use the term https://pubmed.ncbi.nlm.nih.gov/?term=Functional%2Fdissociative+seizures *While Pubmed has >1000 for PNES https://pubmed.ncbi.nlm.nih.gov/?term=psychogenic+nonepileptic+seizures IMO we should wait for the new term to get more traction first. Maybe reasses in a year. [[User:Doc James|<span style="color:#0000f1; background:#FFFFFF;">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) 13:09, 3 March 2026 (UTC) :I don't think that's quite a fair comparison. Looking at secondary (and therefore likely to be [[WP:MEDRS]]) sources and looking since 2023 [https://pubmed.ncbi.nlm.nih.gov/?term=%22functional+seizures%22+OR+%22functional+seizure%22&filter=pubt.booksdocs&filter=pubt.meta-analysis&filter=pubt.review&filter=pubt.systematicreview&filter=years.2023-2026&sort=date search terms for functional seizures] have slightly more results [https://pubmed.ncbi.nlm.nih.gov/?term=%22psychogenic+non-epileptic+seizures%22+OR+%22psychogenic+nonepileptic+seizures%22&filter=pubt.booksdocs&filter=pubt.meta-analysis&filter=pubt.review&filter=pubt.systematicreview&filter=years.2023-2026&sort=date than PNES]. Including terms for Functional Neurological Disorder "AND" seizures and for dissociative seizures gives [https://pubmed.ncbi.nlm.nih.gov/?term=%28%28%28%22functional+seizures%22%29+OR+%28%22functional+seizure%22%29%29%29+OR+%28%22Functional+neurological+disorder%22+AND+%22seizures%22%29+OR+%22dissociative+seizure%22+OR+%22dissociative+seizures%22&filter=pubt.booksdocs&filter=pubt.meta-analysis&filter=pubt.review&filter=pubt.systematicreview&filter=years.2023-2026&sort=date even more results] compared to PNES (83 vs 48). :The results on these sorts of checks will depend on the parameters that are chosen, to be fair. I also think Functional Seizures or Functional/Dissociative seizures would be more [[WP:NPOV]] compliant [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 22:58, 3 March 2026 (UTC) ::I think the term functional/dissociative seizures would make the most sense to adopt as the title of this page since this is the term recommended by the International League Against Epilepsy. However, I agree with Doc James that we can wait a year to see the term gain more traction which I expect will happen. Please see the arguments for adopting this term in this paper: https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.18574 [[User:JF1987|JF1987]] ([[User talk:JF1987|talk]]) 18:51, 4 March 2026 (UTC) *ICD11 uses "6B60.4 Dissociative neurological symptom disorder, with non-epileptic seizures"[https://icd.who.int/browse/2026-01/mms/en#1620688958] [[User:Doc James|<span style="color:#0000f1; background:#FFFFFF;">'''Doc James'''</span>]] ([[User talk:Doc James|talk]] · [[Special:Contributions/Doc James|contribs]] · [[Special:EmailUser/Doc James|email]]) == Recent edits == [[User:Tristario]], Please explain [https://en.wikipedia.org/w/index.php?title=Psychogenic_non-epileptic_seizure&diff=1341767974&oldid=1341745073 this edit] and [https://en.wikipedia.org/w/index.php?title=Psychogenic_non-epileptic_seizure&diff=1341767974&oldid=1341745073 this edit] , giving the removal of two referenced sections here, with the edit summary "removing this sentence as these sources are not WP:MEDRS". The sources seem to use perfectly acceptable journals. One is from 2021, just older than MEDRS likes, but far more recent than several other sources here, and the other was from 2025. What were the issues here? [[User:Johnbod at ILAE|Johnbod at ILAE]] ([[User talk:Johnbod at ILAE|talk]]) 02:02, 7 March 2026 (UTC) :[[WP:MEDRS]] states {{tq|Biomedical information must be based on reliable, third-party published secondary sources}} and that {{tq|Primary sources should generally not be used for medical content, as such sources often include unreliable or preliminary information}}. It recommends the use of secondary sources, such as review articles. :The content I removed was sourced to primary studies, not secondary sources. If you're interested in why primary studies are generally not good sources to use in biomedical articles, there is some explanation at [[WP:WHYMEDRS]] [[User:Tristario|Tristario]] ([[User talk:Tristario|talk]]) 02:14, 7 March 2026 (UTC)
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